PROTAC K-Ras Degrader-3
Product Specifications
CAS Number
3043670-68-1
Target
PROTACs|||Ras
Related Pathways
MAPK|||GPCR/G Protein|||PROTAC
Bioactivity
PROTAC K-Ras Degrader-3 is a PROTAC degrader targeting K-Ras, exhibiting a DC50 value of ? 1 nM against SW620 KRAS G12D and a GI50 value of ? 10 nM in inhibiting the growth of SW620 3D cells. It is used in cancer research.
Smiles
C(N1CC2(C1)CCN(CC2)C=3C=C4C(=CC3)C(=O)N(C4)[C@@H]5C(=O)NC(=O)CC5)C6(C)CCN(CC7(COC=8N=C(C9=C(N8)C(F)=C(N=C9)C=%10C%11=C(C=C(O)C%10)C=CC(F)=C%11CC)N%12C[C@](C)(O)CCC%12)CC7)CC6
Molecular Formula
C57H67F2N9O6
Molecular Weight
1012.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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