MerTK/Axl-IN-1
Product Specifications
CAS Number
3036009-40-9
Target
TAM Receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.
Smiles
C([C@@H](CO)O)N1CCN([C@@H]2C=3C(=CC(=CC3)C4=CC=C(CO[C@@H]5[C@@H](NC(=O)C=6C=C(C=NC6N)C7=C(F)N=CC=C7)CCC5)C=C4)CCC2)CC1
Molecular Formula
C40H47FN6O4
Molecular Weight
694.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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