And1 degrader 1
Product Specifications
CAS Number
3029132-46-2
Target
Others, DNA/RNA Synthesis
Related Pathways
Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Bioactivity
And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.
Smiles
N(CC1=CC(/C=C/C2=CC(Cl)=C(Cl)C=C2)=CC=C1O)C3=CC=C(C=C3)N4CCN(C)CC4
Molecular Formula
C26H27Cl2N3O
Molecular Weight
468.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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