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And1 degrader 1

Product Specifications

CAS Number

3029132-46-2

Target

Others, DNA/RNA Synthesis

Related Pathways

Others, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Bioactivity

And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.

Smiles

N(CC1=CC(/C=C/C2=CC(Cl)=C(Cl)C=C2)=CC=C1O)C3=CC=C(C=C3)N4CCN(C)CC4

Molecular Formula

C26H27Cl2N3O

Molecular Weight

468.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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