PROTAC SMARCA2 degrader-15

SMARCA2 degrader-4 (compound I-332) is a PROTAC-based degrader targeting the SMARCA2 protein, exhibiting a DC50 value of less than 100 nM in A549 cells and achieving a maximum degradation rate (Dmax%) of over 90% after a 24-hour treatment period.

NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)[C@H]5CC[C@H](CC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9