PROTAC SMARCA2 degrader-6
Product Specifications
CAS Number
2568523-72-6
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC molecule targeting SMARCA2, exhibiting a DC50 of less than 100 nM and a maximum degradation rate (Dmax%) of over 90% in A549 cells after 24 hours of treatment.
Smiles
O=C(NCC=1C=CC(=CC1)C=2SC=NC2C)C3N(C(=O)C(NC(=O)C4CC5(C4)CC(CN6CCC(C7=CN=C(N=C7)N8C9CN(C=%10C=C(N=NC%10N)C%11=CC=CC=C%11O)CC8CC9)CC6)C5)C(C)(C)C)CC(O)C3
Molecular Formula
C56H70N12O5S
Molecular Weight
1023.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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