AJI-214
Product Specifications
CAS Number
1395886-20-0
Target
JAK, Aurora Kinase, STAT
Related Pathways
Cell Cycle/Checkpoint, Chromatin/Epigenetic, JAK/STAT signaling, Stem Cells, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
AJI-214 functions as a dual-target inhibitor that specifically blocks Aurora kinase A and JAK2. By directly inhibiting Aurora kinase A, AJI-214 prevents mitotic progression and cell polarity in T cells while concurrently suppressing JAK2 activation to reduce STAT3 phosphorylation. This inhibition decreases the differentiation of TH1 and TH17 cells. AJI-214 is utilized in research focused on the modulation of immune responses and the prevention of graft-versus-host disease (GVHD) .
Smiles
O=C(N)C1=CC=C(C=C1)NC2=NC=C(F)C(=N2)NC=3C=CC=CC3Cl
Molecular Formula
C17H13ClFN5O
Molecular Weight
357.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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