KRC-00715
Product Specifications
CAS Number
2079853-72-6
Target
C-Met/HGFR
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC50 of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC50 of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.
Smiles
FC(F)(F)C=1C=C(C=CC1OCCN2CCOCC2)C3=NC4=C(N=NN4CC5OC6=CC=CN=C6NC5)N=C3
Molecular Formula
C25H25F3N8O3
Molecular Weight
542.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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