SC428
Product Specifications
CAS Number
1898232-70-6
Target
Androgen Receptor, Apoptosis
Related Pathways
Apoptosis, Endocrinology/Hormones
Bioactivity
SC428 acts as an inhibitor of the androgen receptor (AR), specifically targeting the N-terminal domain of AR. This compound effectively diminishes the transactivation of various AR forms, including AR-V7, ARv567es, full-length AR (AR-FL), and its LBD mutants. Additionally, SC428 significantly inhibits AR-FL nuclear translocation, chromatin binding, and AR-regulated gene transcription under androgen stimulation. In vitro, SC428 suppresses the proliferation of tumor cells. In vivo, it inhibits tumor growth in mice transplanted with 22Rv1 cells by inducing apoptosis.
Smiles
N#CC1=CC=C(C=C1C(F)(F)F)NC(=O)NC=CC=2SC=CC2
Molecular Formula
C15H10F3N3OS
Molecular Weight
337.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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