PV1162
Product Specifications
CAS Number
1093793-11-3
Target
Chk
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
PV1162 is a Chk2-specific inhibitor characterized by a potency with an IC 50 value of 0.29 nM. It operates by specifically targeting the gatekeeper-dependent hydrophobic pocket behind the ATP-binding site (adenine-binding region) to inhibit ATP binding to Chk2, effectively suppressing the phosphorylation activity of Chk2. This compound has demonstrated potential for application in cancer therapy.
Smiles
C(NC1=CC=C(\C(=N\NC(=N)N)\CCC)C=C1)(=O)C2=CC=3C(N2)=CC=C(OC)C3
Molecular Formula
C21H24N6O2
Molecular Weight
392.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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