XD2-149
Product Specifications
CAS Number
2710221-08-0
Target
PROTACs, STAT
Related Pathways
Stem Cells, JAK/STAT signaling, PROTAC
Bioactivity
XD2-149 is a PROTAC compound designed to target STAT3. It is composed of the PROTAC target protein ligand Napabucasin, the E3 ligase Thalidomide, and the linker NH2-C5-Azacyclohexane-N-Boc. The conjugate of the E3 ligase and linker is Thalidomide-NH-C5-azacyclohexane-N-Boc, with Thalidomideacid serving as the active comparator for the target protein ligand.
Smiles
O=C(NCCN1CCC(CC1)CCCCCNC2=CC=CC=3C(=O)N(C(=O)C23)C4C(=O)NC(=O)CC4)C=5OC=6C(=O)C=7C=CC=CC7C(=O)C6C5
Molecular Formula
C38H39N5O8
Molecular Weight
693.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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