LDHA-IN-8
Product Specifications
CAS Number
347380-13-6
Target
Dehydrogenase
Related Pathways
Metabolism
Purity
0.9973
Bioactivity
LDHA-IN-8, a small molecule inhibitor of lactate dehydrogenase A (LDHA), inhibits the proliferation of pancreatic and lung cancer cells by inhibiting the activity of LDHA-catalyzed pyruvate in a dose-dependent manner (EC 50=14.54μM), decreasing the intracellular lactate content and increasing the intracellular reactive oxygen species (ROS) levels.
Smiles
O=C1NC(=O)C(=CC=2C=C(N(C=3C=NC=CC3)C2C)C)N1
Molecular Formula
C15H14N4O2
Molecular Weight
282.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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