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Thalidomide-N-methylpiperazine

Product Specifications

CAS Number

2924858-30-8

Target

E3 Ligase Ligand-Linker Conjugate

Related Pathways

PROTAC

Bioactivity

Thalidomide-N-methylpiperazine functions as an E3 Ligase Ligand-Linker Conjugate and is instrumental in the synthesis of PROTAC MLKL Degrader-2. This compound demonstrates antinecroptotic activity in human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model.

Smiles

O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)N4CCN(C)CC4)CC1

Molecular Formula

C18H20N4O4

Molecular Weight

356.38

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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