Thalidomide-N-methylpiperazine
Product Specifications
CAS Number
2924858-30-8
Target
E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC
Bioactivity
Thalidomide-N-methylpiperazine functions as an E3 Ligase Ligand-Linker Conjugate and is instrumental in the synthesis of PROTAC MLKL Degrader-2. This compound demonstrates antinecroptotic activity in human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model.
Smiles
O=C1NC(=O)C(N2C(=O)C3=CC=C(C=C3C2=O)N4CCN(C)CC4)CC1
Molecular Formula
C18H20N4O4
Molecular Weight
356.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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