What is the catalog number for Nic-15?

The catalog number for Nic-15 is T200271.

What sizes are available for Nic-15?

Nic-15 is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does Nic-15 come in?

Nic-15 is available in 3 different pack sizes.

Nic-15 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Nic-15?

Nic-15 is manufactured by Molfinity.

What is the estimated delivery time for Nic-15?

Estimated delivery time for Nic-15 is approximately 10 business day(s), depending on your location.

Nic-15

Product Specifications

CAS Number

2896739-91-4

Target

MTOR, PI3K, Akt

Related Pathways

Cytoskeletal Signaling, PI3K/Akt/mTOR signaling

Bioactivity

Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.