CIB-1476
Product Specifications
Target
NOD-like Receptor (NLR), NF-κB, Pyroptosis, Caspase
Related Pathways
Immunology/Inflammation, NF-κB, Apoptosis, Proteases/Proteasome
Bioactivity
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.
Molecular Formula
C28H28N2O6S
Molecular Weight
520.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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