UNI418
Product Specifications
CAS Number
1802068-51-4
Target
SARS-CoV|||PI3K
Related Pathways
Microbiology/Virology|||PI3K/Akt/mTOR signaling
Bioactivity
UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 ?M) . It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM) . Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM) .
Smiles
N=1C=CC(=CC1)C2=NC3=CC=CC=C3C(=N2)NC4=NNC(=C4)C=5C=CC=CC5
Molecular Formula
C22H16N6
Molecular Weight
364.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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