Cernuumolide J
Product Specifications
CAS Number
2019163-02-9
Target
P38 MAPK, Apoptosis, STAT, JNK, JAK, ERK
Related Pathways
Stem Cells, Angiogenesis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors, MAPK, JAK/STAT signaling, Apoptosis
Bioactivity
Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.
Smiles
O(C(C(C)C)=O)[C@@H]1[C@@]2([C@@]([C@H](OC(/C(=C\C)/C)=O)C(=O)[C@H](C)CCC[C@]1(C)O)(C(=C)C(=O)O2)[H])[H]
Molecular Formula
C24H34O8
Molecular Weight
450.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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