HS-345
Product Specifications
CAS Number
1462329-41-4
Target
Akt, Trk receptor
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors
Bioactivity
HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis) . Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.
Smiles
O=S(=O)(C=1C=C(C=NC1N)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)N(C)C
Molecular Formula
C19H18N6O2S
Molecular Weight
394.45
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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