PROTAC MLKL Degrader-2
Product Specifications
Target
PROTACs, MLK
Related Pathways
PROTAC, MAPK
Bioactivity
PROTAC MLKL Degrader-2, a PROTAC that targets MLKL (Mixed Lineage Kinase), incorporates the PROTAC target protein ligand, E3 ligase ligand Thalidomide, and PROTAC Linker N-Methylpiperazine. The conjugate of the E3 ubiquitin ligase ligand and Linker is Thalidomide-N-Methylpiperazine. This compound exhibits antinecroptotic activity in human cell lines and effectively degrades MLKL in the HT-29 xenograft mouse model.
Molecular Formula
C36H35N9O9S
Molecular Weight
769.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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