Mcl-1 inhibitor 20
Product Specifications
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
Mcl-1 inhibitor20 (compound 47) is an Mcl-1 antagonist with anti-leukemia properties. It binds to the BH3 docking groove of Mcl-1 (Ki=24 nM), occupies the P1 pocket, and interacts with Lys234 and Val249. Mcl-1 inhibitor20 also exhibits good microsomal stability, favorable pharmacokinetic properties, and low cardiotoxicity.
Molecular Formula
C55H61ClFN5O7S
Molecular Weight
990.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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