Tubulin polymerization-IN-68
Product Specifications
CAS Number
2924156-96-5
Target
Caspase|||PARP|||Apoptosis|||Microtubule Associated
Related Pathways
Proteases/Proteasome|||Apoptosis|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||DNA Damage/DNA Repair
Bioactivity
Tubulin polymerization-IN-68 (compound 32) serves as a tubulin inhibitor, disrupting cellular microtubule networks by hindering tubulin polymerization. It also upregulates PARP-1 and caspase-3 expression, thereby inducing apoptosis and exhibiting anticancer properties. Notably, Tubulin polymerization-IN-68 effectively suppresses HepG2 cells with an IC50 of 93 nM and markedly reduces the growth of HepG2 xenograft tumors in nude mice through oral administration.
Smiles
O=C1NC(NC=2C=CC=CC12)C=3C=CC=4NC=CC4C3
Molecular Formula
C16H13N3O
Molecular Weight
263.29
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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