GTCpFE
Product Specifications
CAS Number
1588866-45-8
Target
IκB/IKK, NF-κB
Related Pathways
NF-κB
Bioactivity
GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.
Smiles
C(OC1=CC=C(COC(/C=C/C(OCC)=O)=O)C=C1)(=O)C2=C(OC(C)=O)C=CC=C2
Molecular Formula
C22H20O8
Molecular Weight
412.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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