SIJ1777
Product Specifications
CAS Number
839707-55-0
Target
Apoptosis, Akt, ERK, MEK
Related Pathways
Cytoskeletal Signaling, MAPK, Apoptosis, PI3K/Akt/mTOR signaling
Bioactivity
SIJ1777, a derivative of GNF-7, exhibits potent anticancer effects against melanoma cells harboring BRAFI/II/III mutations. The compound significantly inhibits the activation of MEK, ERK, and AKT. Furthermore, SIJ1777 notably induces apoptosis (cell death) and effectively prevents migration, invasion, and anchorage-independent growth of melanoma cells with BRAFI/II/III mutations.
Smiles
O=C(NC1=CC=C(C(=C1)N2C(=O)N(C3=NC(=NC=C3C2)NC4=NN(C=C4)C)C)C)C5=CC=CC(=C5)C(F)(F)F
Molecular Formula
C26H23F3N8O2
Molecular Weight
536.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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