KL-50
Product Specifications
CAS Number
1161826-19-2
Target
DNA/RNA Synthesis|||Others
Related Pathways
DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Others
Bioactivity
KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.
Smiles
O=C(N)C=1N=CN2C(=O)N(N=NC12)CCF
Molecular Formula
C7H7FN6O2
Molecular Weight
226.17
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15390619 1 Vial
Lentiviral human TSPAN10 sgRNA gene knockout kit - Lentiviral human TSPAN10 sgRNA gene knockout kit (100)
Ask
View Details 