KL-50
Product Specifications
CAS Number
1161826-19-2
Target
DNA/RNA Synthesis, Others
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others
Bioactivity
KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.
Smiles
O=C(N)C=1N=CN2C(=O)N(N=NC12)CCF
Molecular Formula
C7H7FN6O2
Molecular Weight
226.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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