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KL-50

Product Specifications

CAS Number

1161826-19-2

Target

DNA/RNA Synthesis, Others

Related Pathways

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others

Bioactivity

KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.

Smiles

O=C(N)C=1N=CN2C(=O)N(N=NC12)CCF

Molecular Formula

C7H7FN6O2

Molecular Weight

226.17

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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