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SYHA1815

Product Specifications

CAS Number

2760195-67-1

Target

C-RET, VEGFR, c-Myc

Related Pathways

Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint

Bioactivity

SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol/L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol/L) . SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.

Smiles

Cl.O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)C=3C=C(F)C=C(C#CC4=CC=CN=C4N)C3

Molecular Formula

C27H26ClF4N5O

Molecular Weight

547.98

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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