Thalidomide-NH-C10-Boc
Product Specifications
CAS Number
2428400-25-1
Target
E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC
Bioactivity
Thalidomide-NH-C10-Boc (compound S20) serves as a conjugate that combines the E3 ubiquitinase ligand Thalidomide with a PROTAC Linker, enabling the recruitment of Cereblon ubiquitinase. This compound facilitates the coupling of target protein ligands via the PROTAC Linker to create PROTAC molecules capable of inducing degradation. An instance of its function includes the coupling with EP300/CBP ligand 2 to form the PROTAC molecule dCE-2.
Smiles
O=C(OC(C)(C)C)CCCCCCCCCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Molecular Formula
C28H39N3O6
Molecular Weight
513.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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