WK88-1
Product Specifications
CAS Number
958888-32-9
Target
Apoptosis, HSP
Related Pathways
Apoptosis, Metabolism, Cytoskeletal Signaling
Bioactivity
WK88-1, an inhibitor of Hsp90, effectively induces the degradation of various oncogenic signaling molecules, including EGFR, ErbB2, and ErbB3, in the gefitinib-resistant H1975 cell line. This leads to subsequent growth arrest and apoptosis.
Smiles
CO[C@H]1CC\C=C(C)/C(=O)NC2=CC(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)\C=C(C)\[C@H]1OC(N)=O)=CC=C2
Molecular Formula
C28H42N2O6
Molecular Weight
502.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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