AB25583
Product Specifications
CAS Number
2565637-94-5
Target
DNA/RNA Synthesis, Others
Related Pathways
Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair
Bioactivity
AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.
Smiles
O=C(NC1=NN=C(OCC2=CC=C(Cl)C=C2)S1)C=3C=NC=CC3C=4C=CC=CC4OC
Molecular Formula
C22H17ClN4O3S
Molecular Weight
452.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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