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AB25583

Product Specifications

CAS Number

2565637-94-5

Target

DNA/RNA Synthesis, Others

Related Pathways

Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair

Bioactivity

AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.

Smiles

O=C(NC1=NN=C(OCC2=CC=C(Cl)C=C2)S1)C=3C=NC=CC3C=4C=CC=CC4OC

Molecular Formula

C22H17ClN4O3S

Molecular Weight

452.91

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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