NHTD
Product Specifications
CAS Number
2540915-70-4
Target
PDE, Ras
Related Pathways
MAPK, GPCR/G Protein, Metabolism
Bioactivity
NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis) . NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC) .
Smiles
C(=N/NC(=O)C1=C(O)C=C(O)C=C1)\C2=C3C(OC4=C3CCCC4)=CC(C(C)(C)C)=C2O
Molecular Formula
C24H26N2O5
Molecular Weight
422.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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