CLM3
Product Specifications
CAS Number
1312024-59-1
Target
EGFR, Apoptosis, VEGFR, c-RET
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis, JAK/STAT signaling
Bioactivity
CLM3, a pyrazolopyrimidine derivative, functions as a multitargeted tyrosine kinase inhibitor. It exhibits antiproliferative and proapoptotic activities on endothelial and cancer cells, activities that are synergistically enhanced by SN38. The primary mechanism of action for CLM3 involves the inhibition of phosphorylation in tyrosine kinases such as VEGFR-2, EGFR, and RET, along with their associated signaling pathways.
Smiles
N([C@H](C)C1=CC=CC=C1)C2=C3C(N(CCC4=CC=CC=C4)N=C3)=NC=N2
Molecular Formula
C21H21N5
Molecular Weight
343.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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