Ch282-5
Product Specifications
CAS Number
65891-87-4
Target
Apoptosis|||Bcl-2 Family|||Autophagy
Related Pathways
Apoptosis|||Autophagy
Bioactivity
Ch282-5, an orally active inhibitor targeting the Bcl-2 protein, promotes mitochondria-dependent apoptosis (Apoptosis) by disrupting mitophagy and the mTOR pathway. It demonstrates antiproliferative effects on colorectal cancer cells, effective both in vitro and in vivo, while also inhibiting metastasis. Further, Ch282-5 augments Oxaliplatin-induced autophagy (Autophagy) by downregulating Mcl-1 protein and raising platelet count, which helps mitigate the adverse effects of Navitoclax.
Smiles
O=C1C2=C(C(C(C)=C1C(C(C3=C4C(C(C)C)=C(O)C(O)=C3C=NCCS(=O)([O-])=O)=O)=C(C)C4=O)=O)C(C(C)C)=C(O)C(O)=C2C=NCCS(=O)([O-])=O.[Na+].[Na+]
Molecular Formula
C34H34N2Na2O14S2
Molecular Weight
804.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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