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PF-3837

Product Specifications

CAS Number

2772910-13-9

Target

Kinesin, Apoptosis

Related Pathways

Cytoskeletal Signaling, Apoptosis

Bioactivity

PF-3837 is an inhibitor of the Mps1 kinase, with a Ki value of 0.33 nM and an IC50 value of 5.5 nM. It disrupts cell cycle checkpoints by inhibiting the catalytic activity of Mps1, thereby reducing genomic stability and leading to cancer cell apoptosis (Apoptosis) . PF-3837 is utilized in the study of breast cancer.

Smiles

N#CC1=CNC2=NC(=NC(NC(C)(C)CO)=C12)NC3=CC=C(N=C3C)N4CCOCC4

Molecular Formula

C21H26N8O2

Molecular Weight

422.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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