PROTAC SMARCA2/4-degrader-29
Product Specifications
CAS Number
2568273-82-3
Target
PROTACs, Epigenetic Reader Domain
Related Pathways
PROTAC, Chromatin/Epigenetic
Bioactivity
PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.
Smiles
O=C1N(C=2C(=CC(=CC2)[C@@H]3CC[C@@H](CC3)N4CCC(CC4)C=5N=C(C=CN5)N6C7CN(CC6CC7)C=8C=C(N=NC8N)C9=C(O)C=CC=C9)N1C)C%10C(=O)NC(=O)CC%10
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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