IDO1-IN-25
Product Specifications
CAS Number
2841467-86-3
Target
IDO, Indoleamine 2,3-Dioxygenase (IDO)
Related Pathways
Metabolism
Bioactivity
IDO1-IN-25, a dual inhibitor of IDO1/TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS) . Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.
Smiles
O=S(C1=NC=2C=C(Cl)C(Cl)=CC2O1)CC3=CC=C(Cl)C=C3
Molecular Formula
C14H8Cl3NO2S
Molecular Weight
360.64
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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