HRX-0233
Product Specifications
CAS Number
2409140-12-9
Target
Ras, MAPK, Kras
Related Pathways
MAPK
Bioactivity
HRX-0233 is a small molecule inhibitor targeting MAP2K4. In vivo, HRX-0233 effectively reduces tumors in H358 KRASG12C mutant non-small cell lung cancer (NSCLC) without significant toxicity. This compound also prevents feedback activation of receptor tyrosine kinases (RTKs) when used as a monotherapy with the KRAS inhibitor Sotorasib, leading to more sustained and comprehensive inhibition of the MAPK signaling pathway. HRX-0233 holds potential for research in AR-negative prostate cancer, lung cancer, and colon cancer.
Smiles
O=C(C1=CC=C(F)C(NS(=O)(=O)CCC)=C1F)C2=CNC3=NC=C(C=C32)C=4C=NC(=NC4)C5CC5
Molecular Formula
C24H21F2N5O3S
Molecular Weight
497.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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