A-1155905
Product Specifications
CAS Number
2228052-37-5
Target
Caspase, Apoptosis, Bcl-2 Family
Related Pathways
Apoptosis, Proteases/Proteasome
Bioactivity
A-1155905 is an MCL-1 inhibitor with anticancer activity, demonstrating a half maximal inhibitory concentration (IC50) of 33.5 Nm and a dissociation constant (Ki) of 0.58 nM. This compound selectively binds to MCL-1 and possesses sufficient affinity to disrupt the MCL-1-Bim complex in live cells. The induction of death in MCL-1-dependent cell lines by A-1155905 is reliant on caspase proteins and occurs through apoptosis.
Smiles
O=C(O)C1=C(C=2C=CC=C(C=3C(=NN(C3COC4=CC=C(C=C4)N5CCN(C(=O)C)CC5)C)C)C2N1CCN6CCOCC6)CCCOC7=CC=CC=8C(F)=CC=CC78
Molecular Formula
C46H51FN6O6
Molecular Weight
802.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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