XSJ05
Product Specifications
CAS Number
1461652-87-8
Target
Topoisomerase, Apoptosis
Related Pathways
DNA Damage/DNA Repair, Apoptosis
Bioactivity
XSJ05, a derivative of camptothecin (CPT), exhibits anti-cancer activity by inhibiting topoisomerase I (Topo I) . This compound induces DNA double-strand breaks, leading to DNA damage. Furthermore, XSJ05 stifles the growth of colorectal cancer (CRC), halts the cell cycle in the G2/M phase, and induces apoptosis.
Smiles
O=C1N2C(C=3C(C2)=C(C=NNC(NC4=CC=C(C)C=C4)=S)C=5C(N3)=CC=CC5)=CC6=C1COC(=O)[C@@]6(CC)O
Molecular Formula
C29H25N5O4S
Molecular Weight
539.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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