MRT-92
Product Specifications
CAS Number
1428315-82-5
Target
Hedgehog/Smoothened|||Smo
Related Pathways
Stem Cells|||GPCR/G Protein
Bioactivity
MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM) . MRT-92 is utilized for research into cerebellar gliomas.
Smiles
O=C(NC(=N)NC1=CC=C(C(=C1)NC(=O)C2=CC=C(C=C2)CCC=3C=CC=CC3)C)C4=CC(OC)=C(OC)C(OC)=C4
Molecular Formula
C33H34N4O5
Molecular Weight
566.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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