PROTAC SMARCA2/4-degrader-30
Product Specifications
CAS Number
2568276-44-6
Target
Epigenetic Reader Domain, PROTACs
Related Pathways
Chromatin/Epigenetic, PROTAC
Bioactivity
Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.
Smiles
NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5CCN(CC5)[C@@H]6CC[C@H](CC6)C=7C=C8C(=CC7)N(C(=O)N8C)C9C(=O)NC(=O)CC9)C=C(N=N1)C%10=C(O)C=CC=C%10
Molecular Formula
C44H51N11O4
Molecular Weight
797.95
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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