SST0116CL1
Product Specifications
CAS Number
1799802-29-1
Target
EGFR, HSP, Akt, CDK
Related Pathways
Metabolism, Cytoskeletal Signaling, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint
Bioactivity
SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT) . It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.
Smiles
Cl.O=C(NCC)C1=NOC(C=2C=C(C(O)=CC2O)C(C)C)=C1NC(=O)CCN3CCOCC3
Molecular Formula
C22H31ClN4O6
Molecular Weight
482.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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