SST0116CL1
Product Specifications
CAS Number
1799802-29-1
Target
EGFR|||HSP|||Akt|||CDK
Related Pathways
Metabolism|||Cytoskeletal Signaling|||Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||PI3K/Akt/mTOR signaling|||Cell Cycle/Checkpoint
Bioactivity
SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 ?M) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT) . It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 ?M) and exhibits antiproliferative activity, inhibiting tumor growth.
Smiles
Cl.O=C(NCC)C1=NOC(C=2C=C(C(O)=CC2O)C(C)C)=C1NC(=O)CCN3CCOCC3
Molecular Formula
C22H31ClN4O6
Molecular Weight
482.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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