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SD-36 TFA

Product Specifications

Target

Apoptosis|||STAT

Related Pathways

Apoptosis|||JAK/STAT signaling|||Stem Cells

Purity

>99.99%

Bioactivity

SD-36 TFA is a selective and highly efficient STAT3 degrader with a Kd value of about 50 nM.SD-36 has anticancer and antitumor activity, and can break down mutant STAT3 proteins in cells and inhibit STAT3 transcription.SD-36 promotes growth inhibition and induces apoptosis through inhibition of Mcl-1 in gliomas.

Smiles

O=C(NC(C1=CC=CC=C1)C2=CC=CC=C2)[C@H](CCC(N)=O)NC([C@H]3N4[C@](CCN(C[C@@H](C4=O)NC(C5=CC6=CC(C(F)(F)P(O)(O)=O)=CC=C6N5)=O)C(CCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7)=O)([H])CC3)=O.OC(C(F)(F)F)=O

Molecular Formula

C61H63F5N9O14P

Molecular Weight

1272.17

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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