SD-36 TFA
Product Specifications
Target
Apoptosis|||STAT
Related Pathways
Apoptosis|||JAK/STAT signaling|||Stem Cells
Purity
>99.99%
Bioactivity
SD-36 TFA is a selective and highly efficient STAT3 degrader with a Kd value of about 50 nM.SD-36 has anticancer and antitumor activity, and can break down mutant STAT3 proteins in cells and inhibit STAT3 transcription.SD-36 promotes growth inhibition and induces apoptosis through inhibition of Mcl-1 in gliomas.
Smiles
O=C(NC(C1=CC=CC=C1)C2=CC=CC=C2)[C@H](CCC(N)=O)NC([C@H]3N4[C@](CCN(C[C@@H](C4=O)NC(C5=CC6=CC(C(F)(F)P(O)(O)=O)=CC=C6N5)=O)C(CCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7)=O)([H])CC3)=O.OC(C(F)(F)F)=O
Molecular Formula
C61H63F5N9O14P
Molecular Weight
1272.17
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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