PSI-7409 tetrasodium
Product Specifications
CAS Number
1621884-22-7
Target
HCV Protease, Others
Related Pathways
Proteases/Proteasome, Microbiology/Virology, Others
Bioactivity
PSI-7409 tetrasodium, the active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), exhibits specific inhibitory activity against NS5B polymerases of various genotypes, with IC50s being 1.6 μM for GT 1b_Con1, 2.8 μM for GT 2a_JFH1, 0.7 μM for GT 3a, and 2.6 μM for GT 4a, respectively.
Smiles
[Na].[Na].[Na].[Na].[H][C@]1(O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@@]1(C)F)n1ccc(=O)[nH]c1=O
Molecular Formula
C10H16FN2Na4O14P3
Molecular Weight
592.117
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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