Amphotericin B Solution (250 μg/mL), Sterile

Amphotericin B solution is a broad-spectrum polyene antifungal antibiotic. The solution exerts its strongest antifungal activity at pH 6.0 to 7.5. Amphotericin B binds to ergosterol on the fungal cell membrane, which will damage membrane, increase permeability, leak intracellular substances and disrupt normal metabolism. As bacterial cell membranes do not contain ergosterol, amphotericin B is ineffective against bacteria. amphotericin B solution is a sterile, filtered and ready-to-use solution for cell culture, containing 250 μg/mL of amphotericin B. It is recommended for use in cell culture application at 0.25-2.5 μg/mL of amphotericin B. Dilute the solution as experimental needs.