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Polyclonal Anti-Histone H3.1

Product Specifications

Background

Histone H3.1 is a protein that in humans is encoded by the HIST1H3C gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes.

Host

Rabbit

Reactivity

Human, mouse

Immunogen

With a synthetic peptide corresponding to residues of human H3.1 (NP_003520.1) .

Applications

Western Blot (1:5000-20000)

Form

Liquid

Buffer

Histone H3.1 polyclonal antibody detects endogenous levels of total histone H3.1.

References & Citations

1. Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993) . "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". J Cell Biochem 52 (4) : 375–83. 2. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997) . "Human histone gene organization: nonregular arrangement within a large cluster". Genomics 40 (2) : 314–22. 3. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002) . "The human and mouse replication-dependent histone genes". Genomics 80 (5) : 487–98.

Storage Conditions

Store at -20°C for 1 year. Avoid repeated freeze and thaw cycles.

Isotype

IgG1

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