Monoclonal Anti-c-Myc/ MycTag

Product Specifications

Background

C-Myc is a regulator gene that codes for a transcription factor. A mutated version of Myc is found in many cancers, which causes Myc to be constitutively (persistently) expressed. This leads to the unregulated expression of many genes, some of which are involved in cell proliferation and results in the formation of cancer. It may be a potential cancer drug target. c-Myc-tag is one of epitope tags, it is particularly useful for western blotting, immunofluorescence and immunoprecipitation experiments, although they also find use in antibody purification.

Host

Mouse

Reactivity

All

Immunogen

A synthetic peptideEQKLISEEDL conjugated to KLH.

Applications

Western Blot (1:1000-10000) ; Immunofluorescence, IF (1:200-1000) ; Immunoprecipitation, IP (1:100-500)

Form

Liquid

Buffer

In PBS (pH7.4), 50% Glycerol and 0.02% Sodium Azide.

References & Citations

1. Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI (October 2008) . "Modelling Myc inhibition as a cancer therapy". Nature 455 (7213) : 679–83.